Pathway link MTORC1-HIF1A

mTORC1 → HIF-1α

mTORC1 activates HIF-1α.

In one specific setting (prostate cells), mTORC1 turns on a factor usually associated with low oxygen – here it's mTORC1 driving it, not the other way around.

mTOR inhibition reverses Akt-driven prostate intraepithelial neoplasia partly through HIF-1-dependent pathways, placing HIF-1α downstream of mTORC1 in this setting.

The conditions it holds under

Mouse prostate model with pharmacological mTOR inhibition; HIF-1α is one of several pathways implicated in the same experiment.

Time it takes

hours

Step

indirect (through steps not drawn here)

Measured in

mouse

Where in the cell

nucleus

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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