Pathway link CASTOR1-GATOR2
CASTOR1 GATOR2
CASTOR1 inhibits GATOR2.
Without arginine, CASTOR1 holds onto GATOR2 and keeps the pathway switched off.
The conditions it holds under
Human cell biochemistry and structure (CHA2016, SAX2016). The binding is shown in cells; there is no whole-animal or human test in the cited studies.
- Time it takes
- seconds
- Step
- direct (one molecule acts on the other)
- Measured in
- human cells
- Where in the cell
- cytosol
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2016 | M | The CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayCHA2016 Identified CASTOR1 as the direct arginine sensor: when arginine binds CASTOR1, it lets go of GATOR2, switching mTORC1 on. Together with Sestrin2 (leucine) this built the picture of mTORC1 as a cell that literally tastes individual amino acids. |
| 2016 | M | Mechanism of arginine sensing by CASTOR1 upstream of mTORC1SAX2016 CASTOR1 is a direct arginine sensor upstream of mTORC1; structure reveals the arginine-binding mechanism. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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