Pathway link ARG-CASTOR1
Arginine CASTOR1
Arginine inhibits CASTOR1.
Arginine sticks to CASTOR1 the same way leucine sticks to Sestrin2 – the same trick, for a different amino acid.
The conditions it holds under
Human cells and structural work (CHA2016, SAX2016). Shows how arginine is sensed in cells. Whether this sensor matters for arginine supply in a whole animal or a person is not tested here.
- Time it takes
- seconds
- Step
- direct (one molecule acts on the other)
- Measured in
- human cells
- Where in the cell
- cytosol
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2016 | M | The CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayCHA2016 Identified CASTOR1 as the direct arginine sensor: when arginine binds CASTOR1, it lets go of GATOR2, switching mTORC1 on. Together with Sestrin2 (leucine) this built the picture of mTORC1 as a cell that literally tastes individual amino acids. |
| 2016 | M | Mechanism of arginine sensing by CASTOR1 upstream of mTORC1SAX2016 CASTOR1 is a direct arginine sensor upstream of mTORC1; structure reveals the arginine-binding mechanism. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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