Pathway link 4EBP1-LONGEVITY
4E-BP1 Longevity
4E-BP1 activates Longevity.
Keeping 4E-BP switched on extends lifespan in fruit flies on a restricted diet, by protecting their mitochondria.
The conditions it holds under
Fly only, and only under dietary restriction - the effect was not seen on a full diet.
- Time it takes
- long exposure (days to weeks)
- Step
- indirect (through steps not drawn here)
- Measured in
- fly
- Reaches people?
- not tested in people
- How settled
- emerging, few independent studies
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2009 | A | 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in DrosophilaZID2009 Connected the dots between diet, mTOR, and lifespan. 4E-BP, an mTOR target, is upregulated on dietary restriction and here was shown to be REQUIRED for the lifespan boost, working by selectively boosting translation of mitochondrial genes. A rare case pinning a specific mTOR effector to the longevity benefit of eating less. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
← The whole pathway · This link as JSON
Spotted something wrong or out of date about this link?
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Was this page useful?
Thank you. Your answer was counted anonymously.