Xiaoming Yang
Showed as senior author that the liver-secreted protein hepassocin protects against age-related liver senescence and helps the liver regenerate
Corresponding author, State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences · School of Pharmacy, Guangdong Pharmaceutical University · School of Basic Medical Sciences, University of South China
Yang is the corresponding author on the 2026 study identifying Hepassocin (HPS) as a hepatokine that keeps aging livers regenerating. His laboratory traced how HPS activates AMPK through an ANXA2-ERK-p90RSK-LKB1 relay, restraining mTOR activity, and showed that this axis weakens with age — leaving HPS-deficient aged mice with elevated mTOR signalling, impaired autophagy, and a much-reduced ability to recover liver mass after injury.
The work points to restoring HPS or AMPK signalling, rather than blocking mTOR directly, as a route to counteracting age-related liver dysfunction and regeneration failure.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK YAN2026B Senior and corresponding author; his laboratory showed that the hepatokine Hepassocin activates AMPK and protects against liver senescence and regeneration failure. |
Co-authors in the Atlas
People with a profile here who share at least one study with Xiaoming Yang.
- Yang Yang Showed as first author that the liver-secreted protein hepassocin protects against age-related liver senescence and helps the liver regenerate