Wei Shern Lee
First author of the 2021 report that brain mosaic RHEB variants cause a continuum of cortical dysplasia.
Murdoch Children's Research Institute · University of Melbourne
Wei Shern Lee is first author of LEE2021. Three patients with cortical malformations carried brain-restricted RHEB variants that were absent from blood, and the variant load followed the size of the malformation: 2.6% in a small focal lesion, 8.9% in a lobar one and 17.6% in hemimegalencephaly.
In PubMed Wei Shern Lee is listed at the Bruce Lefroy Centre of the Murdoch Children's Research Institute and the Department of Paediatrics at the University of Melbourne.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2021 | H | Gradient of brain mosaic RHEB variants causes a continuum of cortical dysplasia. LEE2021 First author. Higher somatic RHEB variant load goes with a larger dysplastic area and higher mTOR activity. |
Co-authors in the Atlas 5
People with a profile here who share at least one study with Wei Shern Lee.
ShowHide
- Homa Adle-Biassette Neuropathology co-author on two studies of mTOR pathway variants in cortical dysplasia.
- Mathilde Chipaux Paediatric neurosurgery co-author on two studies of mTOR pathway variants in cortical dysplasia.
- Richard J Leventer Last author of the 2021 report on brain mosaic RHEB variants in cortical dysplasia.
- Sara Baldassari First author of the 2019 Acta Neuropathologica cohort study on the genetic basis of focal cortical dysplasia.
- Stéphanie Baulac Last author of the 2019 Acta Neuropathologica cohort study showing that focal cortical dysplasia type 2 is a mosaic mTORopathy.
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.