Vladimir N. Anisimov
Russian gerontologist and oncologist who studied the links between ageing and cancer, and whose group tested drugs such as metformin and rapamycin for effects on lifespan and spontaneous tumours in mice
Head, Department of Carcinogenesis and Oncogerontology (from 1999) and Laboratory of Carcinogenesis and Aging (from 1987), N.N. Petrov Research Institute of Oncology, St. Petersburg · Corresponding Member, Russian Academy of Sciences · President, Gerontological Society of the Russian Academy of Sciences · graduate, First Leningrad Medical Institute · 1945–2024
Vladimir Anisimov was first author of the Atlas study in which female 129/Sv inbred mice given rapamycin for two weeks of every month, from two months of age for life, gained less weight with age, lived longer and developed spontaneous tumours later (ANI2011). The paper, written with Mikhail Blagosklonny, extended earlier lifespan results from genetically heterogeneous mice to an intermittent schedule in a single inbred strain.
Born in Leningrad in 1945, Anisimov joined the N.N. Petrov Research Institute of Oncology in 1965 and spent his career there, heading its Laboratory of Carcinogenesis and Aging from 1987 and its Department of Carcinogenesis and Oncogerontology from 1999. He was a corresponding member of the Russian Academy of Sciences, president of the academy's Gerontological Society and editor of the journal Advances in Gerontology, and wrote several monographs and more than 400 research papers on ageing and cancer. He died in November 2024.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2011 | A | Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice ANI2011 First author: showed that intermittent lifelong rapamycin extended lifespan and delayed spontaneous tumours in female 129/Sv inbred mice. |
Co-authors in the Atlas
People with a profile here who share at least one study with Vladimir N. Anisimov.
- Mikhail V. Blagosklonny Proposed the hyperfunction theory of ageing: TOR signalling that builds a young body never fully switches off, and drives its ageing instead
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