Tatiana M. Moreno

First author of a healthy-aging cohort study showing that human autophagy flux is remodeled with age in a sex- and cell type-specific way, uncoupled from autophagy-gene transcription, and responsive to a mild exercise intervention

Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute

Kumsta Lab, Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California, USA) ↗

Tatiana M. Moreno is the first author of MOR2026, a study from Caroline Kumsta's group at Sanford Burnham Prebys that measured autophagy flux directly across subject-matched human cell types (skin fibroblasts, induced neurons and blood immune cells) from a healthy aging cohort. The study found that autophagy-gene transcription rises with age but autophagic flux itself does not move in lockstep with it: flux fell in male fibroblasts, held steady in female fibroblasts, rose in female induced neurons, and grew more variable in blood cells, becoming associated with reduced physical function only after age 70. A small pilot exercise intervention lowered blood-cell autophagy flux in older adults in parallel with improved physical function, suggesting the measurement is responsive to a real intervention, not just a fixed trait.

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• Caroline Kumsta Senior author of a healthy-aging cohort study measuring autophagy flux directly across human cell types, showing it is sex- and cell type-specific and linked to physical function in older adults

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