Seongbin Kim
Contributed to a 2026 study showing that abnormal ERBB4 in excitatory neurons drives Alzheimer's pathology through mTOR signalling
Neuroscience researcher · KAIST & IBS Center for Synaptic Brain Dysfunctions, South Korea
Seongbin Kim is affiliated with KAIST's Department of Biological Sciences and the IBS Center for Synaptic Brain Dysfunctions. The 2026 Nature study, led by Won-Suk Chung's group, found that a specific population of excitatory neurons abnormally switches on the receptor ERBB4 early in Alzheimer's disease, and that this, acting through mTOR signalling downstream of ERBB4, is necessary for reactive gliosis, synapse loss, amyloid deposition and cognitive decline in mouse models, and sufficient to reproduce these changes apart from amyloid plaques.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Aberrant excitatory neuronal ERBB4 promotes Alzheimer's disease pathology LEE2026 Co-author on the Nature study identifying excitatory-neuronal ERBB4, acting through mTOR signalling, as an early driver of Alzheimer's disease pathology. |
Co-authors in the Atlas 3
People with a profile here who share at least one study with Seongbin Kim.
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- Eunjoon Kim Neuroscientist who directs the IBS Center for Synaptic Brain Dysfunctions and studies synaptic scaffold proteins linked to autism; he contributed to work linking neuronal ERBB4 and mTOR signalling to Alzheimer's pathology
- Se Young Lee Neuroscientist in Won-Suk Chung's group at KAIST and the Institute for Basic Science who studies how neurons, astrocytes and immune cells interact in Alzheimer's disease, and first author of the 2026 Nature study on ERBB4 in excitatory neurons
- Won-Suk Chung Neuroscientist who studies how glial cells (astrocytes and microglia) shape synapses, and senior author of the 2026 study linking neuronal ERBB4 and mTOR signaling to early Alzheimer's disease changes in mice
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