Samantha M. Solon-Biet
Nutrition and ageing researcher at the Charles Perkins Centre who uses the Geometric Framework to study how protein, carbohydrate and fat intake affect lifespan, metabolism and reproduction in mice
Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney (papers to 2026) · earlier also Centre for Education and Research on Aging, Concord Hospital, and ANZAC Research Institute, Sydney
Is it how much we eat, or what we eat, that sets how long we live? In the Atlas study SOL2014, Solon-Biet led an experiment in which mice ate freely from one of 25 diets that differed in protein, carbohydrate, fat and energy content for their whole lives. Calories did not decide lifespan or metabolic health. The ratio of protein to carbohydrate did: low-protein, high-carbohydrate diets gave the longest lives and were associated with lower activation of mTOR, the nutrient sensor, in the liver. The work was done in mice, with Stephen Simpson as senior author.
PubMed lists more than 50 papers by Solon-Biet, nearly all from the Charles Perkins Centre. Earlier records also name the Centre for Education and Research on Aging at Concord Hospital and the ANZAC Research Institute, where Le Couteur's ageing group is based. The papers extend the same diet-mapping approach to the gut microbiome, reproduction and metabolism, for example a 2016 study showing that protein intake shapes which gut bacteria thrive, and a 2026 study showing that different protein, carbohydrate and fat balances suit mouse mothers during pregnancy and during milk feeding.
The current position is stated from the 2026 PubMed affiliation, the Charles Perkins Centre and School of Life and Environmental Sciences at the University of Sydney.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2014 | A | The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice SOL2014 First author: ran the 25-diet lifelong mouse study showing that the protein-to-carbohydrate ratio, not calorie intake, shaped lifespan and metabolic health. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Samantha M. Solon-Biet.
ShowHide
- David A. Sinclair Geneticist of aging at Harvard Medical School, known for work on sirtuins, NAD+ and the idea that aging stems from a loss of epigenetic information, who appears in this Atlas as a co-author on two mouse lifespan studies
- Stephen J. Simpson Biologist who began with how locusts choose their food and is known for the Geometric Framework for nutrition, which shows that the balance of protein, carbohydrate and fat shapes health and lifespan; inaugural academic director of the Charles Perkins Centre
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.