Rong Wang
Researcher in Viviana Pérez's group at the Linus Pauling Institute who studied how rapamycin holds back cellular senescence, and first author of work separating its effect on the senescence secretory profile from its Nrf2-dependent effect on cell-cycle arrest
Linus Pauling Institute and Department of Biochemistry & Biophysics, Oregon State University (papers with Viviana Pérez, 2014–2022)
Rong Wang was first author of the Atlas study from Viviana Pérez's group at Oregon State University asking whether rapamycin needs the transcription factor Nrf2 to hold back cellular senescence (WAN2017). In mouse fibroblasts, human WI38 cells and Nrf2-knockout mice, rapamycin still lowered beta-galactosidase staining and the inflammatory secretory profile (SASP) without Nrf2, but needed Nrf2 to lower p16 and p21 and to switch on autophagy. The study pointed to lower STAT3 activation as one route for the SASP effect.
Wang published with the Pérez group at the Linus Pauling Institute from 2014 to 2022, on rapamycin and dietary restriction in mouse liver, rapamycin and bone in young adult mice, and senescence markers in the brains of Alzheimer's disease model mice. No current institutional page was found, so the affiliation shown is the one on the Atlas paper.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2017 | M | Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism WAN2017 First author: showed in mouse and human fibroblasts and Nrf2-knockout mice that rapamycin lowers the senescence secretory profile without Nrf2 but needs Nrf2 to lower p16 and p21. |
Co-authors in the Atlas
People with a profile here who share at least one study with Rong Wang.
- Viviana I. Pérez Aging biologist who studied protein homeostasis in long-lived species and how rapamycin and dietary restriction act in mice, and who now directs the National Institute on Aging's Division of Aging Biology
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