Ömer H. Yilmaz
Pathologist and stem-cell biologist who studies how diet and nutrient sensing control intestinal stem cells; as a postdoc with David Sabatini he showed that calorie restriction acts on the stem-cell niche through mTORC1 in Paneth cells
Associate Professor of Biology (tenured 2022), Koch Institute for Integrative Cancer Research, MIT · gastrointestinal pathologist, Massachusetts General Hospital and Harvard Medical School · own lab since 2014 · visiting postdoctoral fellow with David Sabatini, Whitehead Institute · thesis work with Sean Morrison, University of Michigan Medical School
Yilmaz Lab, Koch Institute for Integrative Cancer Research and Department of Biology, MIT (Cambridge, Massachusetts, USA) ↗ Lab lineagetrained under David M. Sabatini →
Ömer Yilmaz was first author of the Atlas study showing in mice that calorie restriction increases intestinal stem-cell function by acting on the Paneth cells that form their niche (YIL2012). Restriction lowered mTORC1 activity in Paneth cells, forcing mTORC1 back on cancelled the effect, and a short course of rapamycin copied it; the niche signal ran through higher Bst1 and the messenger cyclic ADP ribose.
Yilmaz did his thesis work on blood stem cells with Sean Morrison at the University of Michigan and then spent two years as a visiting postdoctoral fellow in David Sabatini's lab, where the Atlas study was done. He started his own lab at MIT's Koch Institute in 2014 and also works as a gastrointestinal pathologist at Massachusetts General Hospital. His group studies how diet, including fasting and high-fat diets, changes intestinal stem cells and the early steps of colon cancer.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake YIL2012 First author: showed in mice that calorie restriction boosts intestinal stem cells by lowering mTORC1 in their Paneth-cell niche. |
Co-authors in the Atlas
People with a profile here who share at least one study with Ömer H. Yilmaz.
- David M. Sabatini Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM
- Dudley W. Lamming Showed as a postdoc that rapamycin's harm to glucose metabolism comes largely from its effect on mTORC2, while the lifespan benefit tracks mTORC1. His Wisconsin lab studies intermittent rapamycin dosing and how restricting dietary protein or single amino acids affects metabolism and ageing
- Shomit Sengupta Showed that mTORC1 controls whether the liver makes ketone bodies during fasting, and now leads biology for drug discovery at a metabolic-disease biotech
Every researcher with a profile →
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