Michael Wong
Pediatric epileptologist whose lab studies how epilepsy develops, with a focus on mTOR in tuberous sclerosis complex and brain injury; senior author of the mouse study in which rapamycin prevented epilepsy in a TSC model.
Professor of Neurology, Pediatrics and Neuroscience, and Allen P. and Josephine B. Green Professor of Pediatric Neurology, Washington University in St. Louis · Director, Washington University Tuberous Sclerosis Center · pediatric neurology residency and epilepsy fellowship, Washington University · MD and PhD (neuroscience), UT Southwestern Medical School · BA, Princeton University
Wong Lab, Department of Neurology, Washington University School of Medicine (St. Louis, Missouri, USA) ↗ Lab lineage1 direct trainee →
Michael Wong was senior author of the 2008 Annals of Neurology study led by Ling-Hui Zeng (ZEN2008). In mice lacking Tsc1 mainly in glia, rapamycin given before symptoms prevented epilepsy and early death, and rapamycin given after seizures had started suppressed them and prolonged survival, while reversing mTOR pathway activation and astrogliosis in the brain. The study, in mice, provided evidence that mTOR inhibition can act on epilepsy itself in TSC, and Wong was later a site investigator on the EXIST-3 trial of everolimus in patients (FRE2016).
Wong trained at Princeton and UT Southwestern, then in pediatric neurology and epilepsy at Washington University in St. Louis, where he has stayed. His lab studies epileptogenesis and seizure-induced brain injury in genetic and acquired rodent models, with the mTOR pathway as a central theme, and he directs the university's Tuberous Sclerosis Center.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2008 | A | Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex ZEN2008 Senior author: rapamycin prevents epilepsy and early death in Tsc1 glial knockout mice, and suppresses seizures once they have begun. |
Co-authors in the Atlas
People with a profile here who share at least one study with Michael Wong.
- Ling-Hui Zeng Pharmacologist who studies mTOR signalling in epilepsy; as a researcher in Michael Wong's group she was first author of the mouse study showing that rapamycin prevents epilepsy in a tuberous sclerosis model.
Every researcher with a profile →
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