Marco Sardiello
Geneticist who, in Andrea Ballabio's group, helped show that lysosomal genes share a promoter motif and are switched on together by the transcription factor TFEB; his lab now works on lysosomal storage diseases, especially the neuronal ceroid lipofuscinoses.
Professor of Pediatrics, Division of Genetics and Genomic Medicine, Washington University School of Medicine in St. Louis · previously Department of Molecular and Human Genetics, Baylor College of Medicine, Houston · Telethon Institute of Genetics and Medicine (TIGEM), Naples
Sardiello Lab, Division of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine (St. Louis, Missouri, USA) ↗ ORCID0000-0001-6484-0250 ↗
Portrait: Baylor College of Medicine
Marco Sardiello was first author of the 2009 Science paper from Andrea Ballabio's group at TIGEM in Naples (SAR2009). The team found that most lysosomal genes are expressed in a coordinated way and share a promoter motif (later called the CLEAR element) bound by TFEB. When lysosomes were overloaded, TFEB moved into the nucleus, and extra TFEB increased lysosome numbers and degradation capacity in cultured cells. mTOR was not studied in this paper; later work tied TFEB to mTORC1.
After TIGEM, Sardiello ran a lab in the Department of Molecular and Human Genetics at Baylor College of Medicine in Houston and then moved to Washington University in St. Louis, where he is Professor of Pediatrics. His lab characterises poorly annotated genes linked to inherited disease, with a focus on lysosomal biology and the neuronal ceroid lipofuscinoses.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2009 | M | A gene network regulating lysosomal biogenesis and function SAR2009 First author: lysosomal genes form a coordinated network with a shared promoter motif regulated by TFEB, which drives lysosome biogenesis. |
Co-authors in the Atlas
People with a profile here who share at least one study with Marco Sardiello.
- Andrea Ballabio Discovered that the transcription factor TFEB is a master switch for building lysosomes (SAR2009) and for autophagy. His lab was one of the groups that showed in 2012 that mTORC1 keeps TFEB out of the nucleus from the lysosome surface, and later (2020) that constitutive TFEB activation drives the kidney disease of Birt-Hogg-Dubé syndrome
Every researcher with a profile →
Thank you. Your answer was counted anonymously.
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.