Katrin Düvel
First author of the study showing that mTORC1 switches on a metabolic gene program through HIF1α and SREBP, driving glycolysis, the pentose phosphate pathway and lipid synthesis
Director of Research Compliance and Integrity, Wyss Institute at Harvard University (since 2018) · Research Compliance Officer, Harvard FAS and SEAS · Postdoctoral fellow, Manning lab, Harvard School of Public Health (2006–2010) · research on yeast TOR signalling at Princeton University · PhD, Friedrich-Alexander University Erlangen
Research Compliance and Integrity, Wyss Institute for Biologically Inspired Engineering at Harvard University (Boston, Massachusetts, USA) ↗ Lab lineagetrained under Brendan D. Manning →
Katrin Düvel is first author of DUV2010, done as a postdoctoral fellow in Brendan Manning's lab at the Harvard School of Public Health. Using cells with constitutively active mTORC1 (TSC2 loss) and rapamycin, together with gene expression and metabolite profiling, the team found that mTORC1 activation is enough to drive glycolysis, the oxidative pentose phosphate pathway and de novo lipid synthesis. This ran through HIF1α and SREBP1/2 target genes, and SREBP activation needed S6K1.
Before the Manning lab she worked at Princeton University on TOR signalling in budding yeast, including a 2003 Molecular Cell paper on the role of Tap42 in rapamycin-induced changes in gene expression. She earned her PhD at Friedrich-Alexander University in Erlangen. After about 14 years in basic and applied cancer research at Princeton, the Harvard School of Public Health and the Dana-Farber Cancer Institute, she moved into research administration. Since April 2018 she has been Director of Research Compliance and Integrity at the Wyss Institute at Harvard.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | M | Activation of a metabolic gene regulatory network downstream of mTOR complex 1 DUV2010 First author: mTORC1 activates a HIF1α- and SREBP-driven metabolic gene program that supports glycolysis, the pentose phosphate pathway and lipid synthesis. |
Co-authors in the Atlas
People with a profile here who share at least one study with Katrin Düvel.
- Brendan D. Manning Was among the groups that in 2002 identified TSC2 as a direct target of Akt (MAN2002), linking insulin and PI3K signalling to mTORC1, and later found TBC1D7 as the third subunit of the TSC complex. His lab has shown how mTORC1 turns growth signals into the synthesis of lipids and nucleotides
- Sue Menon Showed insulin controls mTORC1 by moving the TSC complex on and off the lysosome
Every researcher with a profile →
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