Jonas Boritz Kristiansen
Exercise biologist at Aarhus University, working with Kristian Vissing, who studies how aging changes muscle's response to mechanical load and to food
Exercise Biology, Department of Public Health, Aarhus University, Vissing group (papers 2025–2026)
Muscles grow when they are stretched and loaded, and mTORC1, the growth-control complex, is one of the main switches that turns that signal into new protein. Older muscle often responds less, a problem called anabolic resistance. Jonas Boritz Kristiansen is first author of a 2026 study from Kristian Vissing's exercise biology group at Aarhus University that tested which part of the signal is lost (KRISTIANSEN2026). Muscles from adult and old female mice were stretched in a dish. mTORC1 signalling switched on just as strongly in old muscle as in young, but a second stress pathway, JNK-SMAD2L, responded less with age. So, at least in this mouse model, the mTORC1 sensor for stretch seems to stay intact with age.
Kristiansen's other papers fit the same theme. A 2026 systematic review and meta-analysis, as first author, pooled 46 human studies and found that older adults make muscle protein slightly more slowly than young adults at rest and after a meal, but respond about as well to exercise. A 2025 rat study, with the same group, looked at how weeks of voluntary wheel running affect oxidative stress and DNA repair in the brain. No institutional profile was found, so career stage is not given.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Aging preserves mTORC1 but attenuates JNK-SMAD2L signaling sensitivity to passive stretch-induced tension development in isolated mouse skeletal muscle. KRISTIANSEN2026 First author: showed in ex vivo mouse muscle that stretch activates mTORC1 equally in adult and old females while JNK-SMAD2L signalling is blunted with age. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Jonas Boritz Kristiansen.
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- Kristian Kjær Vissing Studies the control of protein balance in skeletal muscle and how this knowledge might counter muscle loss.
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