Jiqin Lian
Biochemist studying deubiquitinase signalling in autophagy and metabolic disease
Corresponding author, Department of Clinical Biochemistry, Army Medical University (Third Military Medical University), Chongqing, China
Lian is a corresponding author in the Department of Clinical Biochemistry at Army Medical University (Third Military Medical University) in Chongqing, China. The 2026 study from Lian's group traced how cells sense starvation at the molecular level: ERK-driven phosphorylation stabilizes the deubiquitinase OTUB1, which in turn boosts DEPTOR to hold mTOR in check and switch on autophagy.
The work extended this mechanism to disease relevance, showing in a mouse model that reactivating the fasting-triggered OTUB1-mTOR axis could blunt Western-diet-driven mTOR activation and slow the progression of MASLD.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | Phosphorylation of OTUB1 promotes autophagy initiation under starvation SUN2026B Corresponding author; the laboratory identified the phosphorylation-dependent OTUB1-DEPTOR-mTOR mechanism linking starvation to autophagy initiation and its relevance to fasting-based protection against MASLD. |
Co-authors in the Atlas
People with a profile here who share at least one study with Jiqin Lian.
- Liangbo Sun Researcher studying phosphorylation-based control of autophagy initiation and its role in metabolic liver disease