Jian Yin
Structural biologist at Tsinghua University who used cryo-electron microscopy to show how the human amino acid transporter PAT1 (SLC36A1) recognises and moves its cargo
State Key Laboratory of Membrane Biology and Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University (affiliation on PubMed papers)
Jian Yin is the first author of YIN2026, a structural study of PAT1 (also called SLC36A1), a human transporter that carries small amino acids across membranes together with protons. Earlier work by other groups had shown that PAT1 sits on lysosomes, the cell's recycling compartments, and helps move amino acids out of them, which affects how mTORC1, the cell's nutrient sensor, is switched on. Yin and colleagues used cryo-electron microscopy, a method that freezes proteins and images them with electrons, to see PAT1 empty and with different amino acids bound. The structures show that the transporter grips many different amino acids in a similar way. The study is about the shape and mechanism of the protein; the mTORC1 link comes from the earlier work.
PubMed lists Yin at Tsinghua University's School of Life Sciences on about a dozen structural papers on membrane transporters, most of them with M. Yang as senior author, from the State Key Laboratory of Membrane Biology and the Beijing Advanced Innovation Center for Structural Biology.
Because Yin is a common surname, only papers from this Tsinghua structural biology group were counted. No official profile was found, so training and position are not given.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1) YIN2026 First author: solved cryo-EM structures of the human proton-coupled amino acid transporter PAT1 (SLC36A1) with and without bound amino acids. |
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