Jens Otto L Jørgensen
Clinical professor of endocrinology at Aarhus University who studies growth hormone, the pituitary and adrenal glands and metabolism in people, and senior author of a trial showing that high-dose resveratrol did not improve metabolism in obese men
Clinical Professor, Department of Clinical Medicine (Hormone and Bone Diseases), Aarhus University · Department of Endocrinology and Internal Medicine, Aarhus University Hospital
Department of Clinical Medicine (Hormone and Bone Diseases), Aarhus University, and Department of Endocrinology and Internal Medicine, Aarhus University Hospital (Aarhus, Denmark) ↗ ORCID0000-0001-7408-1526 ↗
Jens Otto L Jørgensen is the senior author of the Atlas study POU2013, with Morten Møller Poulsen as first author. Resveratrol, a compound from grape skins, had looked promising in rodents, where it seemed to copy some effects of calorie restriction. The Aarhus team tested it properly in people: obese men took a high dose or a placebo for four weeks, and the researchers measured insulin sensitivity, how the body burned fuel, blood pressure and body composition.
None of these changed with resveratrol. The trial was short and small, but it was carefully controlled, and it showed that the rodent results did not carry over to this group of people. A later trial from the same Aarhus groups, with Jørgensen as a co-author, found no benefit of resveratrol in the metabolic syndrome either (2017).
Jørgensen's main research line is growth hormone, the pituitary hormone that drives growth in children and shapes fat, muscle and sugar metabolism in adults. The group studies how the hormone acts in muscle and fat, including in people with acromegaly, the condition caused by too much growth hormone. Recent papers show that excess growth hormone causes reversible scarring (fibrosis) in muscle and fat of patients with acromegaly (2026) and compare methods for measuring body composition in acromegaly (2025). A 2014 study from the resveratrol trial examined growth hormone signalling in muscle and fat of obese people.
Jørgensen is a clinical professor (klinisk lærestolsprofessor) in the Department of Clinical Medicine at Aarhus University, in the unit for hormone and bone diseases. The university profile describes research on hormones and metabolism, especially diseases of the pituitary and adrenal glands, with both clinical studies in patients and laboratory work.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2013 | H | High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition POU2013 Senior author: led the randomised trial in which four weeks of high-dose resveratrol did not change insulin sensitivity, blood pressure or body composition in obese men. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Jens Otto L Jørgensen.
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- Morten Poulsen Endocrinologist at Aarhus University Hospital who led one of the first careful human trials of high-dose resveratrol, which found no metabolic benefit in obese men
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