Haijuan Yang
Solved, as first author in the Pavletich lab, the crystal structure of the mTOR kinase and the structure of mTORC1 activated by RHEB
Senior Research Scientist, Structural Biology Program, MSKCC (Pavletich Lab)
Pavletich Lab, Structural Biology Program, Memorial Sloan Kettering Cancer Center (New York, New York, USA) ↗ ORCID0009-0004-5033-1147 ↗
Portrait: Memorial Sloan Kettering Cancer Center
First author on the 2013 crystal structure of the mTOR kinase (YAN2013), revealing the FRB 'gatekeeper' domain. First author again in 2017 (YAN2017) on cryo-EM structures of mTORC1 alone and bound to RHEB, plus a crystal structure of a truncated mTOR–PRAS40 complex, revealing the allosteric activation/inhibition mechanism.
Both studies from Nikola Pavletich's lab (who has his own profile in the Atlas).
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2013 | M | mTOR kinase structure, mechanism and regulation YAN2013 Solved the crystal structure of the mTOR kinase, revealing the FRB gatekeeper domain. |
| 2017 | M | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 YAN2017 Solved structures of mTORC1 bound to RHEB/PRAS40, revealing the allosteric activation mechanism. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Haijuan Yang.
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- Hyo J Yang 2 shared studies Researcher in Nikola Pavletich's structural biology laboratory at Memorial Sloan Kettering and co-author of the two Nature papers that showed the atomic structure of mTOR and of mTORC1
- Nikola P. Pavletich 2 shared studies Solved the crystal structure of the mTOR kinase, revealing the FRB domain as a gatekeeper of its active site, and later showed how RHEB switches mTORC1 on and PRAS40 blocks it
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