Edward T. Chouchani
Senior/corresponding author on a bioRxiv preprint showing dietary restriction licenses autophagy through oxidation of a single cysteine (Cys19) on the core autophagy protein ATG5
Department of Cancer Biology, Dana-Farber Cancer Institute · Department of Cell Biology, Harvard Medical School, Boston, MA, USA
Edward Chouchani is corresponding author of SHI2026 (bioRxiv), which built a tissue-resolved atlas of cysteine oxidation under dietary restriction and found that oxidation of Cys19 on ATG5 is required for it to bind ATG10 and form the ATG5-ATG12 conjugate that builds the autophagosome. Mice lacking this redox switch fail to induce autophagy on nutrient restriction and die rapidly, showing a single oxidized cysteine gates the autophagic response to fasting.
Added to the Atlas 2026-10-03; profile is a stub pending a second corpus study (no portrait yet).
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | PP | Redox activation of ATG5 licenses autophagy upon nutrient restriction SHI2026 Senior/corresponding author of a preprint showing a single oxidized cysteine (Cys19) on ATG5 licenses autophagosome formation and gates the autophagic response to nutrient restriction. |
Co-authors in the Atlas
People with a profile here who share at least one study with Edward T. Chouchani.
- William B. Mair Studies how nutrient and energy sensors, and dietary restriction, control the rate of ageing, using models from yeast to mammals
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