Edmond Y. W. Chan
Studies how nutrient-sensing kinases, including ULK1, mTORC1 and AMPK, control autophagy and mitochondrial stress responses; in Sharon Tooze's lab he helped identify ULK1 as a kinase needed for starvation-induced autophagy in human cells.
Associate Professor, Department of Biomedical and Molecular Sciences, Queen's University · earlier group leader at the University of Strathclyde, Glasgow · Secretory Pathways Laboratory (Sharon Tooze), Cancer Research UK London Research Institute
Edmond Chan was first author of the 2007 Journal of Biological Chemistry study from Sharon Tooze's laboratory at the Cancer Research UK London Research Institute (CHA2007). A kinase-targeted siRNA screen in human HEK293 cells picked out ULK1: knocking it down, but not ULK2, blocked autophagy after amino-acid starvation and after rapamycin, which fits ULK1 acting downstream of mTOR. The team also mapped separate parts of ULK1 needed for its effects and its localisation.
Chan later ran an autophagy lab at the University of Strathclyde in Glasgow, working on ULK1 signalling, AMPK and mTORC1, and the autophagy-lysosome pathway in cancer. His lab is now at Queen's University in Kingston, Ontario, where it studies mitochondria as stress sensors, mitophagy and how cancer cells survive therapy.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2007 | M | siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy CHA2007 First author: a kinome siRNA screen in human cells identifies ULK1, not ULK2, as required for starvation- and rapamycin-induced autophagy. |
Co-authors in the Atlas
People with a profile here who share at least one study with Edmond Y. W. Chan.
- Sharon A. Tooze Cell biologist who studies how autophagosomes are built in mammalian cells; her lab has identified several mammalian Atg proteins and helped show that ULK1 is needed for starvation-induced autophagy.
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