Dominic Winter
Proteomics researcher who uses mass spectrometry to map lysosomal proteins and their modifications, including phosphorylation, in health and disease.
Professor, lysosomal proteome dynamics group, University of Duisburg-Essen (previously Institute of Biochemistry and Molecular Biology, University of Bonn)
Portrait: University of Duisburg-Essen (photo: UDE/Anke Wälischmiller)
Dominic Winter leads a research group on lysosomal proteome dynamics. The group page says it has moved from the University of Bonn to the Research Center One Health Ruhr at the University of Duisburg-Essen. Lysosomes are the cell's main digestive compartments, and their proteins are present in very low amounts, so special mass spectrometry methods are needed to study them.
His group develops ways to enrich lysosomes and to measure their proteins, phosphorylation, protein partners and half-lives. This fits the 2026 preprint in the Atlas, led by Prasanna Muthukottiappan, which links cholesterol exchange between the ER and the lysosome to lysosome movement.
The preprint reports that this control runs through mTOR-dependent phosphorylation of LAMTOR1, part of the Ragulator complex that anchors the Rag GTPases on the lysosome. It is a preprint and has not been peer reviewed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | PP | ER-Lysosome Cholesterol Exchange Regulates Lysosomal Motility Through mTOR-Dependent LAMTOR1 Phosphorylation MUT2026 Preprint reporting that ER-lysosome cholesterol exchange regulates lysosome motility via mTOR-dependent phosphorylation of LAMTOR1 in the Ragulator complex; Winter is senior (last) author. |
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