Darcy A. Krueger
Child neurologist who led the first trial of an mTOR inhibitor for brain tumours in tuberous sclerosis complex
Director, Tuberous Sclerosis Clinic · Associate Professor of Clinical Pediatrics and Neurology · Cincinnati Children's Hospital Medical Center
Tuberous Sclerosis Clinic, Cincinnati Children's Hospital Medical Center (Cincinnati, Ohio, USA) ↗
Portrait: Cincinnati Children's
Darcy Krueger is a child neurologist who directs the Tuberous Sclerosis Clinic at Cincinnati Children's Hospital Medical Center, where he is Associate Professor of Clinical Pediatrics and Neurology. His work focuses on how tuberous sclerosis complex (TSC) causes disease and on treatments that could prevent or reverse it.
He earned both a PhD (2000) and an MD (2002) at Saint Louis University and trained in pediatrics, neurology and child neurology in Cincinnati. He was a founding member and the first director (2011–2013) of the TSC Clinical Research Consortium.
In the Atlas he is first author of KRU2010 in the New England Journal of Medicine. In 28 patients with TSC, the mTOR inhibitor everolimus shrank subependymal giant-cell astrocytomas (a type of brain tumour) by at least 30% in three out of four. This open-label study led to the first FDA-approved treatment for TSC in 2010.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | H | Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis KRU2010 First author: everolimus shrank TSC-related brain tumours by 30% or more in 75% of 28 patients (open-label, humans). |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Darcy A. Krueger.
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- David N. Franz Led the EXIST-1 trial showing that the mTOR inhibitor everolimus shrinks the brain tumours (SEGAs) of tuberous sclerosis, and helped run the first sirolimus trial for its kidney tumours
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