Christopher J. Potter
As a PhD student with Tian Xu at Yale, showed in Drosophila that Akt directly phosphorylates Tsc2 and breaks up the Tsc1-Tsc2 complex, one of several 2002 papers that connected insulin-Akt signalling to TSC. He now studies insect olfaction
Professor of Neuroscience, Johns Hopkins University School of Medicine · postdoc with Liqun Luo, Stanford (2002–2010) · PhD in Genetics with Tian Xu, Yale (1996–2002)
Potter Lab, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA) ↗ Lab lineagetrained under Tian Xu →
Christopher Potter did his PhD in Tian Xu's lab at Yale. In the Atlas study he was first author on work in fruit flies showing that Akt phosphorylates Drosophila Tsc2 at two conserved sites, that Tsc2 lacking these sites no longer responds to Akt, and that such a mutant blocks Akt-driven cell growth (POT2002). Other groups reported the same Akt-to-TSC2 link in mammalian cells in the same year.
After a postdoc with Liqun Luo at Stanford, where he moved into neuroscience, Potter set up his own lab at Johns Hopkins. His group builds genetic tools to study how the insect brain detects and responds to odours, in Drosophila and in the malaria mosquito Anopheles gambiae.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2002 | M | Akt regulates growth by directly phosphorylating Tsc2 POT2002 First author: showed in Drosophila that Akt phosphorylates Tsc2 at Ser924 and Thr1518 and that a Tsc2 mutant lacking these sites blocks Akt-driven growth. |
Co-authors in the Atlas
People with a profile here who share at least one study with Christopher J. Potter.
- Tian Xu Drosophila geneticist whose Yale lab helped show that Akt controls growth by phosphorylating the tumour suppressor Tsc2, linking the insulin pathway to TSC
Every researcher with a profile →
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