Calvin K. Yip
Structural biologist who uses electron microscopy to study large protein machines; as a postdoc at Harvard Medical School he determined a cryo-EM structure of human mTORC1, and his lab now studies the autophagy machinery.
Professor, Department of Biochemistry and Molecular Biology, University of British Columbia · postdoctoral fellow, Harvard Medical School (2006–2010) · PhD (2006) and BSc (2001), University of British Columbia
Calvin Yip was first author of the 2010 Molecular Cell study (YIP2010), done in the Department of Cell Biology at Harvard Medical School with Thomas Walz, David Sabatini and Seong Kang. The team purified active human mTORC1 and determined its shape by cryo-EM at about 26 angstrom: an obligate dimer held together by mTOR and Raptor. FKBP12-rapamycin gradually broke the purified complex apart while Torin1 did not, leading the authors to propose that rapamycin blocks S6K1 and 4E-BP1 phosphorylation by different mechanisms; this disassembly is an in vitro result.
Yip studied at the University of British Columbia, did postdoctoral work at Harvard Medical School and returned to UBC, where he is a professor of biochemistry and molecular biology. His lab studies the structure and biochemistry of the autophagy machinery, chromatin-modifying complexes and rare genetic diseases such as Vici syndrome.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | M | Structure of the human mTOR complex I and its implications for rapamycin inhibition YIP2010 First author: cryo-EM shows human mTORC1 is a rhomboid dimer, and FKBP12-rapamycin gradually disassembles the purified complex. |
Co-authors in the Atlas
People with a profile here who share at least one study with Calvin K. Yip.
- David M. Sabatini Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM
- Seong A. Kang Contributed to the Sabatini-lab studies that identified PRAS40 and DEPTOR, two of the cell's own mTOR inhibitors, and to the first characterisation of the mTOR inhibitor Torin1
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