Brian G. Barnett
First author of the six-month, placebo-controlled trial of low-dose rapamycin in healthy pet dogs
Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine (present address given in the 2023 paper) · Texas A&M University College of Veterinary Medicine & Biomedical Sciences (affiliation at the time of the trial)
Brian G. Barnett is a veterinary researcher who has published with the cardiology group at Texas A&M University's College of Veterinary Medicine & Biomedical Sciences, including Sonya Gordon, Sonya Wesselowski and Ashley Saunders, on heart disease and heart function in dogs. His 2023 paper gives his present address as the Department of Small Animal Medicine and Surgery at the University of Georgia.
He is first author of a 2023 placebo-controlled trial in Frontiers in Veterinary Science in which 17 healthy client-owned dogs received low-dose rapamycin or placebo for six months. The drug caused no clinically significant adverse events, but heart function measured by echocardiography did not differ significantly from placebo, so the heart benefit hinted at by an earlier 10-week trial was not reproduced. The work was supported by the Dog Aging Project.
The timeline below follows Barnett's contribution gathered in this Atlas.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2023 | A | A masked, placebo-controlled, randomized clinical trial evaluating safety and the effect on cardiac function of low-dose rapamycin in 17 healthy client-owned dogs BAR2023 First author of a placebo-controlled six-month trial of low-dose rapamycin in 17 healthy dogs: well tolerated, but no significant change in heart function. |
Co-authors in the Atlas
People with a profile here who share at least one study with Brian G. Barnett.
- Kate E. Creevy Runs the veterinary side of the Dog Aging Project and leads TRIAD, the trial testing whether rapamycin extends lifespan in pet dogs
- Matt Kaeberlein Extended TOR/aging research from yeast to mice to pet dogs
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