Boris Shor
First author of the 2010 Journal of Biological Chemistry study on mTOR, Maf1 and RNA polymerase III transcription.
Wyeth Research, Pearl River, NY
Boris Shor is first author of SHO2010. Using the mTOR active-site inhibitor WYE-125132, the team found that Maf1, the repressor of RNA polymerase III, loses its phosphorylation at Ser75 when mTOR is blocked, accumulates in the nucleus and lowers the output of pre-tRNA.
In PubMed he is listed in Discovery Oncology at Wyeth Research in Pearl River, New York.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | M | Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells SHO2010 First author. mTOR inhibition dephosphorylates Maf1 and turns down RNA polymerase III transcription. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Boris Shor.
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- Ker Yu Last author of the 2010 Journal of Biological Chemistry study on mTOR, Maf1 and RNA polymerase III transcription.
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