Oliver's mTOR Atlas Evidence Platform
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Beatrice Rivalta

First author of a multicenter registry analysis comparing rapamycin and leniolisib in a rare immune disorder

Clinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy

Beatrice Rivalta works in the Clinical Immunology and Vaccinology Unit at Bambino Gesù Children's Hospital in Rome.

First author of a 2026 retrospective ESID registry analysis of 95 patients with Activated PI3-Kinase-δ Syndrome (APDS), comparing real-world outcomes of rapamycin and the targeted PI3Kδ inhibitor leniolisib — finding comparable response rates for lymphoproliferation, with treatment-limiting adverse events reported only in the rapamycin group.

Milestones in the Atlas

YearEvidenceStudy
2026 H Leniolisib and rapamycin in Activated PI3-Kinase-δ-syndrome: a retrospective ESID registry-based analysis RIV2026 First author: multicenter registry of 95 APDS patients finds rapamycin and leniolisib produce comparable responses, but only rapamycin caused treatment-limiting adverse events.

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