Antonio Lanzavecchia
Human immunologist known for work on antigen presentation, memory T and B cells and methods for isolating human monoclonal antibodies; senior author of the study showing that L-arginine changes T-cell metabolism and survival independently of mTOR.
Head, Human Immunology Program, INGM, Milan, and Senior Research Fellow, Vir Biotechnology · founding Director, Institute for Research in Biomedicine, Bellinzona (until 2020) · Professor of Human Immunology, ETH Zurich (2009–2017) · member, Basel Institute for Immunology (from 1983) · MD, University of Pavia (1976), with specialisation in paediatrics and infectious diseases
Lanzavecchia Lab, Human Immunology Program, Istituto Nazionale di Genetica Molecolare (INGM) (Milan, Italy) ↗ Lab lineage1 direct trainee →
Antonio Lanzavecchia was senior author of the 2016 Cell study (GEI2016) in which his group, with Roger Geiger as first author, tracked metabolites and proteins in activated human T cells. Raising L-arginine moved the cells from glycolysis towards oxidative phosphorylation, gave them central-memory-like features and better survival, and improved their anti-tumour activity in mice. The paper states that this effect was independent of mTOR, since L-arginine did not change S6K1 or 4E-BP phosphorylation and rapamycin changed metabolism in a different way.
Lanzavecchia studied medicine at the University of Pavia and specialised in paediatrics and infectious diseases. He worked at the University of Genoa and then at the Basel Institute for Immunology, and was the founding director of the Institute for Research in Biomedicine in Bellinzona. He is the scientific founder of Humabs BioMed, now part of Vir Biotechnology, where he is a senior research fellow, and his academic research continues at INGM in Milan. He is an international member of the US National Academy of Sciences (2016).
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2016 | M | L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity GEI2016 Senior author: L-arginine shifts activated human T cells towards oxidative metabolism and longer survival, through nuclear sensors and not through mTOR (human cells in culture, mouse tumour models). |
Co-authors in the Atlas
People with a profile here who share at least one study with Antonio Lanzavecchia.
- Roger Geiger Studies how metabolism regulates T-cell responses against tumours; first author of the study showing that raising L-arginine shifts human T cells towards oxidative metabolism and longer survival, an effect the authors found to be independent of mTOR.
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