Antoine Marçais
Studies how mTOR and cell metabolism control natural killer (NK) cells; first author of the mouse study showing that NK cells need mTOR to respond to IL-15 during their development and activation.
Group leader, NK cell immunometabolism, LYACTS team (Thierry Walzer), CIRI, Lyon · earlier work on CD8 T cells at INSERM U503, Lyon (mid-2000s)
Antoine Marçais was first author of the 2014 Nature Immunology study (MAR2014) from Thierry Walzer's team. It showed that low IL-15 mainly switches on STAT5 in NK cells while higher IL-15 is needed to switch on mTOR, and that mice whose NK cells lack mTOR have almost no mature NK cells in the periphery. mTOR-deficient NK cells also failed to grow and to make normal amounts of granzyme B after activation, and oral rapamycin made NK-cell rejection of target cells less efficient. Human data in the paper are limited to NK cells from healthy donors stimulated in culture.
Marçais now leads the NK cell immunometabolism group inside the LYACTS team at CIRI in Lyon, which asks how mTOR, glycolysis and NK-cell reactivity are linked and why mTOR activation is impaired in exhausted NK cells. He supervised the PhD of Lucie Fallone on how IL-15 and IL-18 regulate the mTOR pathway in NK cells (defended 2024).
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2014 | A | The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells MAR2014 First author: NK cells need mTOR, switched on by high-dose IL-15, to mature and to become fully activated (mouse genetics, plus human NK cells in culture). |
Co-authors in the Atlas
People with a profile here who share at least one study with Antoine Marçais.
- Thierry Walzer Studies how natural killer (NK) cells develop and become active; his team showed in mice that IL-15 signalling through mTOR is needed for NK-cell maturation and activation.
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