Akanksha Swarup
PhD candidate in Timothy Bolger's lab at the University of Georgia who studies how cancer mutations in the RNA helicase DDX3X change the cell's protein-making response to stress
PhD candidate, BCMB program, Bolger Lab, University of Georgia · master's studies at Maastricht University and Savitribai Phule Pune University · undergraduate degree, Savitribai Phule Pune University
Akanksha Swarup is the first author of SWA2026, done in Timothy Bolger's lab at the University of Georgia. DDX3X is an RNA helicase, a protein that unwinds folded messenger RNA so ribosomes can read it. It is often mutated in medulloblastoma, a brain cancer of children. The team copied these cancer mutations into DED1, the yeast version of the gene. The mutant yeast kept growing in rapamycin, the drug that blocks the growth complex TORC1. After TORC1 was blocked, the mutant cells made more protein from messages with simple, unfolded starts, many of them growth messages. This hints at how mutant DDX3X might let tumour cells escape a brake set by TORC1, but it is yeast work and does not show the effect in tumours.
In 2024 Swarup and Bolger also wrote a review in Biomolecules on the role of DDX3X in medulloblastoma. The lab page lists Swarup as a PhD candidate in the Biochemistry and Molecular Biology (BCMB) program. Swarup did undergraduate studies at Savitribai Phule Pune University in India and master's studies at Maastricht University in the Netherlands and Savitribai Phule Pune University.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | Medulloblastoma-associated mutations in the RNA helicase DDX3X/DED1 cause defects in the translational response to TORC1 inhibition SWA2026 First author: modelled medulloblastoma DDX3X mutations in yeast DED1 and found rapamycin-resistant growth with more translation of simple-start growth messages after TORC1 inhibition. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Akanksha Swarup.
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- Timothy A. Bolger Studies how RNA helicases such as yeast Ded1 and human DDX3X control protein production under stress, including after TORC1 inhibition.
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