Jay N. Joshi
Showed mTORC1 activity itself rises and falls across the cell cycle, not just in response to nutrients
PhD candidate, Graduate Program in Cellular and Molecular Pharmacology, Rutgers University · Valvezan Lab, Center for Advanced Biotechnology and Medicine (CABM) · BA
Valvezan Lab, Rutgers (Piscataway, New Jersey, USA) ↗ Lab lineagetrained under Alexander J. Valvezan → Bluesky@jaynjoshi.bsky.social ↗
Portrait: Center for Advanced Biotechnology and Medicine, Rutgers
As a PhD student in Alexander Valvezan's lab, Jay Joshi showed that mTORC1 activity does not simply track nutrient and growth-factor availability — it also oscillates across the cell cycle on its own, running lowest during mitosis and G1 and highest during S phase and G2. The oscillation runs through the TSC complex but is independent of the pathway's classical upstream inputs, including Akt and Mek/Erk signalling, and this timing — not just the average activity level — shapes how sensitive a cell is to autophagy induction at different points in the cycle.
The work continues a direct line from Brendan Manning's lab, where Valvezan himself trained alongside Dibble and Menon on the same TSC–mTORC1 axis, now carried forward at Rutgers into the added dimension of cell-cycle timing.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2024 | M | mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction JOS2024 Shows mTORC1 activity itself oscillates across the cell cycle — lowest in mitosis/G1, highest in S/G2 — independent of known upstream inputs, and that this timing shapes autophagy sensitivity. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Jay N. Joshi.
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- Alexander J. Valvezan Showed as a Manning-lab postdoc that mTORC1 matches nucleotide production to demand, creating a weak point that can be targeted in tumours with TSC loss. His Rutgers lab found that mTORC1 activity rises and falls through the cell cycle and helps drive entry into mitosis
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