Darlene E. Berryman
Showed that growth hormone reshapes fat tissue in a depot-specific way that links body composition to metabolic aging
Professor of Biomedical Sciences & Associate Dean for Research and Innovation, Ohio University Heritage College of Osteopathic Medicine · Registered & Licensed Dietitian (2001) · PhD Nutritional Sciences, Cornell University (1994) · BS Biology, University of Virginia (1988)
Institute for Molecular Medicine and Aging, Ohio University Heritage College of Osteopathic Medicine (Athens, Ohio, USA) ↗ ORCID0000-0003-4240-9229 ↗
Portrait: Ohio University
In LIST2026, mice expressing a GH receptor antagonist lived longer and, at two years of age, were less frail — but also had increased adiposity, reflecting Berryman's long-running argument that fat tissue quality/distribution, not just quantity, drives metabolic outcomes under altered GH signaling. In DUR2026, adult-onset GH receptor deletion improved insulin sensitivity in males, and single-cell liver sequencing revealed sex-dimorphic remodeling.
Trained as a nutritional scientist at Cornell after a biology degree at UVA, she later earned dietetic credentials — unusual among molecular biologists. She built her program on how GH excess/deficiency reshapes adipose tissue.
She now serves as Associate Dean for Research and Innovation and has held interim leadership of the renamed Institute for Molecular Medicine and Aging.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Growth Hormone Receptor Antagonism Extends Lifespan LIST2026 Contributes body-composition/frailty phenotyping showing lifespan-extending GH receptor antagonism paradoxically increases adiposity even while improving frailty markers. |
| 2026 | A | Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex-Specific Hepatic Transcriptional Changes at Single-Cell Resolution DUR2026 Co-authors single-cell liver transcriptomics showing sex-specific metabolic remodeling after adult-onset GH receptor deletion. |
Co-authors in the Atlas 4
People with a profile here who share at least one study with Darlene E. Berryman.
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- Edward O. List 2 shared studies Carries out mouse studies, in John Kopchick's group, on how disrupting growth hormone receptor signaling extends mammalian lifespan
- John J. Kopchick 2 shared studies Discovered the growth hormone receptor antagonist that became the acromegaly drug pegvisomant (Somavert), and studies how blocking growth hormone signalling extends lifespan in mice
- Silvana Duran-Ortiz Researcher in John Kopchick's group at Ohio University who studies how switching off growth hormone action, even in middle age, lengthens life in mice
- Yuji Ikeno Pathologist at the Barshop Institute for Longevity and Aging Studies in San Antonio whose examinations of tissues from aged mice help ageing studies tell whether an intervention changes disease, especially cancer, late in life
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