Andrew L. Markhard
Contributed, as a Sabatini-lab researcher, to the discovery that Ragulator docks mTORC1 on the lysosome, and now studies metabolite signals that tell the body it has eaten
Ph.D. student, NYU Grossman School of Medicine · Research Scientist, Long Lab, Stanford · Lab Manager, Mootha Lab, Broad/MGH (2012–2022) · Research staff, Sabatini Lab, Whitehead/MIT
Long Lab, Stanford (formerly Mootha Lab, Broad/MGH) (Stanford, California, USA) ↗
Portrait: Long Lab, Stanford University
Part of team showing (SAR2006) prolonged rapamycin also blocks mTORC2 assembly and Akt signalling in many cell types (later linked in mice to rapamycin's insulin resistance, LAM2012). Part of team (SAN2010) showing Ragulator recruits Rag GTPases to the lysosomal surface, docking mTORC1 next to Rheb.
Decade as Mootha-lab manager mapping mitochondrial proteins, then Stanford metabolomics (2024 Nature: enzyme PTER/taurine; 2026 Nature Metabolism: python-derived gut-brain feeding signal). Now pursuing a PhD at NYU.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2006 | M | Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB SAR2006 Co-author: prolonged rapamycin treatment blocks mTORC2 assembly and Akt/PKB signalling in many cell types (later linked in mice to rapamycin's insulin resistance, LAM2012). |
| 2010 | M | Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids SAN2010 Helped show Ragulator recruits Rag GTPases to the lysosomal surface, docking mTORC1 next to Rheb. |
Co-authors in the Atlas 8
People with a profile here who share at least one study with Andrew L. Markhard.
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- David M. Sabatini 2 shared studies Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM
- Dos D. Sarbassov Discovered rictor as a Sabatini-lab postdoc, in parallel with Michael Hall's lab, defining mTOR Complex 2, and showed that this complex is the long-sought kinase that phosphorylates Akt on serine 473. He also found that prolonged rapamycin treatment can block mTORC2 assembly
- Liron Bar-Peled Showed as a Sabatini-lab graduate student that Ragulator switches the Rag GTPases on, acting as their GEF. He also discovered GATOR1 and GATOR2; GATOR1 switches the Rags off and its genes are mutated in some cancers
- Peggy P. Hsu Identified, in parallel with Yonghao Yu's group, Grb10 as an mTORC1 substrate that feeds back to dampen insulin and growth-factor signalling, and now studies the earliest steps of lung cancer as a physician-scientist
- Roberto Zoncu Showed as a postdoc that mTORC1 senses amino acids from inside the lysosome, through the v-ATPase and Ragulator. His Berkeley lab has since mapped how the Rag GTPases and the folliculin complex switch mTORC1 on, and how lysosomal cholesterol feeds into the same system
- Shomit Sengupta Showed that mTORC1 controls whether the liver makes ketone bodies during fasting, and now leads biology for drug discovery at a metabolic-disease biotech
- Siraj M. Ali Worked in the Sabatini lab on the papers that discovered raptor, mLST8 and rictor, and on the finding that the rictor-mTOR complex phosphorylates Akt. He later moved into cancer genomics and clinical diagnostics
- Yasemin Sancak Showed as a Sabatini-lab graduate student, in parallel with Kun-Liang Guan's lab, that the Rag GTPases relay amino-acid signals to mTORC1, and that Ragulator anchors them to the lysosome where mTORC1 is switched on. She also identified PRAS40 as an insulin-regulated inhibitor of mTORC1
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