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PRODID:-//Oliver's mTOR Atlas//Events//EN
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METHOD:PUBLISH
BEGIN:VEVENT
UID:aacr-nci-eortc-international-conference-on-molecular-targets-1kj9bc4@mt
 or-atlas.org
DTSTAMP:20261102T142257Z
DTSTART;VALUE=DATE:20271026
DTEND;VALUE=DATE:20271031
SUMMARY:AACR-NCI-EORTC International Conference on Molecular Targets and Ca
 ncer Therapeutics 2027
LOCATION:Sheraton Grand Chicago Riverwalk\, Chicago\, IL\, USA
DESCRIPTION:Small\, drug-development-focused conference jointly organised b
 y AACR\, the NCI and the EORTC\; the main venue where first-in-human data 
 on novel targeted agents are reported before journal publication.\n\nWhy i
 t matters for mTOR (★★): Direct provenance for the Atlas's own Schram 
 2025 entry: the first-in-human phase 1/1b data for RMC-5552\, the first bi
 -steric mTORC1-selective inhibitor in the clinic\, were presented here (Ab
 stract C020\, 2023) before the Clinical Cancer Research paper. This is whe
 re Open Question 2 (inhibit mTORC1 without affecting mTORC2) is being answ
 ered in humans rather than in mice: bi-steric selectivity relieves the mTO
 RC2-mediated hyperglycaemia that limited earlier pan-mTOR inhibitors. Also
  the venue for 4E-BP1 pharmacodynamics and mucositis management.\n\nConfer
 ence site: https://www.aacr.org/meeting/aacr-nci-eortc-international-confe
 rence-molecular-targets-and-cancer-therapeutics/\n\nIn Oliver's mTOR Atlas
 : https://mtor-atlas.org/events/#ev-aacr-nci-eortc-international-conferenc
 e-on-molecular-targets-1kj9bc4
URL:https://www.aacr.org/meeting/aacr-nci-eortc-international-conference-mo
 lecular-targets-and-cancer-therapeutics/
TRANSP:TRANSPARENT
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