{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.0",
  "corpus_snapshot": "2026-10-01T14:49:35+0200",
  "source_commit": "03bba2194c4832a1bcdfb704d54dd458ab0df021",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "sid": "SAB1994",
  "title": "RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs",
  "authors": "Sabatini DM et al.",
  "year": 1994,
  "journal": "Cell",
  "doi": "10.1016/0092-8674(94)90570-3",
  "pmid": "7518356",
  "pmcid": null,
  "evidence": {
   "code": "M",
   "label": "Molecular — cells, biochemistry, structure",
   "note": "this describes the kind of study, not its quality"
  },
  "category": "Mechanism",
  "model_system": "Rat brain (protein purification)",
  "peer_reviewed": true,
  "finding": "Discovery of the protein RAFT1 (today's mTOR) as the direct target of the FKBP12-rapamycin complex; one of three 1994 reports (with Brown et al. and Chiu et al.) that identified mammalian TOR, three years after TOR was found in yeast.",
  "url": "https://mtor-atlas.org/study/SAB1994/",
  "api_url": "https://mtor-atlas.org/api/v1/studies/SAB1994.json",
  "abstract_excerpt": "The immunosuppressants rapamycin and FK506 bind to the same intracellular protein, the immunophilin FKBP12. The FKB12-FK506 complex interacts with and inhibits the Ca(2+)-activated protein phosphatase calcineurin. The target of the FKBP12-rapamycin complex has not yet been identified. We report that a protein complex containing 245 kDa and 35 kDa components, designated rapamycin and FKBP12 targets 1 and 2 (RAFT1 and RAFT2), interacts with FKBP12 in a rapamycin-dependent manner.",
  "abstract_truncated": true,
  "extracted_findings": {
   "intervention": "Biochemical (FKBP12-rapamycin affinity purification)",
   "target": "RAFT1 (mTOR/FRAP) / FKBP12",
   "species": "Rat brain tissue (biochemical purification)",
   "effect": "Identifies RAFT1 (mammalian TOR) as the FKBP12-rapamycin target, homologous to yeast TORs"
  },
  "entities": [
   {
    "id": "rapamycin",
    "name": "Rapamycin",
    "type": "Drug"
   },
   {
    "id": "mtor",
    "name": "mTOR",
    "type": "Gene/Protein"
   }
  ],
  "relations": {
   "supports": [
    "FKBP12-MTORC1",
    "RAPA-MTORC1"
   ],
   "conflicts_with": []
  },
  "questions": [],
  "related_studies": [
   "BCH2026",
   "BIT2016",
   "BJE2010",
   "CAC2010"
  ]
 }
}