{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "ULK1-FNIP1",
  "claim": "ULK1 inhibits FLCN / FNIP1/2",
  "source": {
   "name": "ULK1",
   "entity": "ulk1"
  },
  "target": {
   "name": "FLCN / FNIP1/2",
   "entity": "flcn-fnip1-2"
  },
  "effect": "inhibits",
  "type": "phosphorylation",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "When lysosomes are stressed, ULK1 (or its relative TBK1) phosphorylates FNIP1 at S296 on the lysosome. This switches the FLCN-FNIP complex off, so mTORC1 can no longer hold TFEB in the cytoplasm and TFEB moves into the nucleus.",
  "mechanism_beginner": "ULK1 tags FNIP1, which turns FLCN off and lets TFEB escape mTORC1's grip.",
  "context": null,
  "boundary": "Human cell lines and ATP6V1B2-mutant follicular lymphoma samples; a nutrient-independent lysosomal-stress route, and TBK1 can substitute for ULK1. Single study.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "ESP2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/ULK1-FNIP1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/ULK1-FNIP1.json"
 }
}