{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "4823f516b720e66843f0b75952daf5ccc5279a7c20c0cb7c0d1ac126ff6ca768",
  "corpus_snapshot": "2026-10-24T21:34:23+0200",
  "source_commit": "8f0f14a10e115daab72bb59e5bf8c63eda1daeb8",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "ULK1-AUTOPHAGY",
  "claim": "ULK1 activates Autophagy",
  "source": {
   "name": "ULK1",
   "entity": "ulk1"
  },
  "target": {
   "name": "Autophagy",
   "entity": "autophagy"
  },
  "effect": "activates",
  "type": "functional-consequence",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": null,
  "map_band": "autophagy",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "Freed ULK1 nucleates the autophagosome - the self-eating programme that recycles damaged parts and is the leading candidate mechanism for mTOR inhibition's benefits.",
  "mechanism_beginner": "Freed ULK1 kicks off autophagy – the cell's recycling programme, and the leading idea for why blocking this pathway might be beneficial.",
  "context": "LC3-II accumulation, the standard readout for this step, marks autophagosome number, not flux: it rises whether autophagosomes are being made faster or degraded slower (e.g. under lysosomal/fusion block), so it cannot alone distinguish increased autophagy from stalled autophagy. A flux assay (e.g. LC3-II with and without a degradation blocker, or p62 turnover) is needed to tell the two apart.",
  "boundary": "Mammalian cell studies (GAN2009, HOS2009, EGA2010). Autophagosome initiation is shown in cultured cells. Whether autophagy carries the benefits of mTOR inhibition in whole animals is not tested by these sources.",
  "boundary_tags": [],
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "GAN2009",
    "HOS2009",
    "EGA2010",
    "CHA2007",
    "RUS2013"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/ULK1-AUTOPHAGY/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/ULK1-AUTOPHAGY.json"
 }
}