{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "4823f516b720e66843f0b75952daf5ccc5279a7c20c0cb7c0d1ac126ff6ca768",
  "corpus_snapshot": "2026-10-24T21:34:23+0200",
  "source_commit": "8f0f14a10e115daab72bb59e5bf8c63eda1daeb8",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "TSC-MTORC1",
  "claim": "TSC1/TSC2 inhibits mTORC1",
  "source": {
   "name": "TSC1/TSC2",
   "entity": "tsc1-tsc2"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "inhibits",
  "type": "signal-relay",
  "directness": "indirect",
  "timescale": "seconds",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human",
   "mammalian cells"
  ],
  "mechanism": "The TSC complex is the pathway's main tumour suppressor. Inherit one broken copy and lesions grow wherever the second copy is lost - the clearest human evidence that mTORC1 activity drives tissue overgrowth.",
  "mechanism_beginner": "The TSC brake is the pathway's main tumour-suppressor. Inherit one broken copy of the gene and growths appear wherever the second copy is also lost. (This arrow skips a step for simplicity – TSC actually acts through Rheb first.)",
  "context": "Deliberately compressed: TSC acts on Rheb rather than directly on mTORC1. Kept as one link so the overview reads cleanly.",
  "boundary": "Human cell lines, Drosophila, mouse and cell studies, one open-label human trial (KRU2010) and human disease genetics. The human evidence comes from disease caused by TSC loss, not from healthy tissue.",
  "boundary_tags": [],
  "note": "This is the edge that turns the biochemistry into a disease.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "established",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "H",
    "label": "Human study"
   },
   "supporting": [
    "TEE2003",
    "INOK2003",
    "KRU2010",
    "CHEN2026C",
    "ZHANG2026",
    "DEM2014",
    "SEN2010",
    "GAO2002",
    "TEE2002",
    "KWI2002",
    "DEY2008",
    "POL2015",
    "TSA2012",
    "BAT2013",
    "ZEN2008"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/TSC-MTORC1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/TSC-MTORC1.json"
 }
}