{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "4823f516b720e66843f0b75952daf5ccc5279a7c20c0cb7c0d1ac126ff6ca768",
  "corpus_snapshot": "2026-10-24T21:34:23+0200",
  "source_commit": "8f0f14a10e115daab72bb59e5bf8c63eda1daeb8",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "TRANSL-MUSCLE",
  "claim": "Protein synthesis activates Muscle growth",
  "source": {
   "name": "Protein synthesis",
   "entity": "protein-synthesis"
  },
  "target": {
   "name": "Muscle growth",
   "entity": "muscle-growth"
  },
  "effect": "activates",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "days",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "mouse",
   "mouse myotubes"
  ],
  "mechanism": "Sustained protein synthesis is what physically builds muscle; in mice, Akt/mTOR signalling is necessary and sufficient for hypertrophy (BOD2001). In people, blocking mTOR blunts the short-term rise in muscle protein synthesis after exercise (DRU2009); whether that changes how much muscle is gained over months was not measured.",
  "mechanism_beginner": "Ongoing protein-building is what physically builds muscle; in mice, the signals that drive it are needed for muscle growth and are enough to cause it. In people, blocking mTOR blunts the rise in muscle protein-building after a single bout of exercise, but how much muscle is gained over months under the drug was not measured.",
  "context": "Requires mechanical load. mTORC1 activation without loading does not reproduce healthy hypertrophy, and constitutive activation alone is not sufficient.",
  "boundary": "Mouse (BOD2001) and cultured myotubes (ROM2001). The human study DRU2009 is cited on the step before this one (LOAD-MTORC1): rapamycin blocked the rise in muscle protein synthesis 1-2 h after one bout of contractions (and also blocked ERK1/2). It did not measure muscle growth, so it is not evidence for this arrow.",
  "boundary_tags": [],
  "note": "2026-10-10: DRU2009 moved off this arrow. It measured short-term protein synthesis, not muscle growth, and stays cited on LOAD-MTORC1. Human relevance plausible.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "BOD2001",
    "ROM2001"
   ],
   "conflicting": [
    "LAP2026"
   ]
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/TRANSL-MUSCLE/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/TRANSL-MUSCLE.json"
 }
}