{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "TORIN-MTORC2",
  "claim": "ATP-competitive mTOR inhibitors inhibits mTORC2",
  "source": {
   "name": "ATP-competitive mTOR inhibitors",
   "entity": "atp-competitive-mtor-inhibitors"
  },
  "target": {
   "name": "mTORC2",
   "entity": "mtorc2"
  },
  "effect": "inhibits",
  "type": "competitive-inhibition",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "pm",
  "map_band": "pm",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "The same active site is present in both complexes, so an ATP-competitive inhibitor cannot distinguish them.",
  "mechanism_beginner": "mTORC1 and mTORC2 use the same ATP-binding pocket, so a drug that blocks the pocket hits both and cannot choose. That is thought to explain why this class of drugs causes more metabolic and immune side effects than rapamycin-type drugs, but the size of that effect has only been seen in cell studies and has not been measured in patients.",
  "context": null,
  "boundary": "Explains the metabolic and immunological toxicity of this class relative to rapalogs; the magnitude in patients is not established from these cell-line studies.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Pharmacological",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "THO2009",
    "FEL2009",
    "JAN2010",
    "ROD2011",
    "GAR2009"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/TORIN-MTORC2/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/TORIN-MTORC2.json"
 }
}