{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "TORIN-MTORC1",
  "claim": "ATP-competitive mTOR inhibitors inhibits mTORC1",
  "source": {
   "name": "ATP-competitive mTOR inhibitors",
   "entity": "atp-competitive-mtor-inhibitors"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "inhibits",
  "type": "competitive-inhibition",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "Occupies the mTOR active site in competition with ATP, so inhibition does not depend on obstructing substrate access and is not partial in the way rapalog inhibition is.",
  "mechanism_beginner": "Torin sits in the spot where mTOR holds its energy molecule ATP, so it shuts the kinase down whatever the kinase is about to modify. Rapamycin leaves part of mTORC1's work running; Torin does not, which is how researchers learned how much rapamycin had been missing. This comes from cell-culture work, not from patients.",
  "context": null,
  "boundary": "Cell-line pharmacology. Clinical development of this class has been limited by toxicity attributed to simultaneous mTORC2 inhibition, which is precisely what the bi-steric design tries to avoid.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Pharmacological",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "THO2009",
    "FEL2009",
    "CHR2009",
    "JAN2010",
    "ROD2011",
    "GAR2009"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/TORIN-MTORC1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/TORIN-MTORC1.json"
 }
}