{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "STRESS-AMPK",
  "claim": "Energy & cellular stress activates AMPK",
  "source": {
   "name": "Energy & cellular stress",
   "entity": "energy-cellular-stress"
  },
  "target": {
   "name": "AMPK",
   "entity": "ampk"
  },
  "effect": "activates",
  "type": "allosteric-activation",
  "directness": "direct",
  "timescale": "seconds",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "AMPK does not read ATP directly - it reads the ratio of AMP and ADP to ATP. As ATP is consumed, AMP and ADP accumulate and bind the gamma subunit, which is the actual switch: it activates AMPK allosterically and protects the activating Thr172 phosphate from removal. AMPK is the cell's low-fuel sensor, and mTORC1 is one of the first things it shuts off.",
  "mechanism_beginner": "When the cell's fuel runs low, AMPK switches on – it's the cell's low-battery alarm, and one of the first things it does is shut mTORC1 off.",
  "context": "Drawn as a fuel-gauge for readability. The proximal trigger is the AMP(ADP)/ATP ratio binding the AMPK gamma subunit, not 'ATP running down' as a single variable - AMP and ADP both compete with ATP for the same regulatory sites.",
  "boundary": "XIA2011 (crystal structure and biochemistry of mammalian AMPK) demonstrates that AMP binding to the gamma regulatory domain promotes phosphorylation and protects against dephosphorylation, and that ADP binds too. GWI2008 and ZHO2001 show downstream consequences. DEM2026 (IDH3 and citrate in AML stem cells) does not test AMP/ADP binding; its place on this edge needs the curator's decision.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "GWI2008",
    "ZHO2001",
    "DEM2026",
    "XIA2011"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/STRESS-AMPK/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/STRESS-AMPK.json"
 }
}