{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "SLC38A9-RAG",
  "claim": "SLC38A9 activates Rag GTPases",
  "source": {
   "name": "SLC38A9",
   "entity": "slc38a9"
  },
  "target": {
   "name": "Rag GTPases",
   "entity": "rag-gtpases"
  },
  "effect": "activates",
  "type": "binding",
  "directness": "direct",
  "timescale": "seconds",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "SLC38A9 sits in the lysosomal membrane and reads arginine on the inside. Arginine-bound SLC38A9 acts as an exchange factor that loads RagA with GTP, switching the Rag dimer on (SHE2018B); it also pumps essential amino acids, including leucine, back out into the cytosol.",
  "mechanism_beginner": "SLC38A9 sits in the lysosome's wall, senses arginine inside, and then flips RagA into its \"on\" shape, telling the Rag proteins there's enough.",
  "context": null,
  "boundary": "Mammalian cell studies and purified-protein work (REB2015, WAN2015, JUN2015, WYA2017, SHE2018B). Cell and biochemical evidence; whole-animal and human relevance are not tested here.",
  "note": "Five independent studies - one of the best-supported edges in the sensor branch.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "REB2015",
    "WAN2015",
    "JUN2015",
    "WYA2017",
    "SHE2018B"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/SLC38A9-RAG/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/SLC38A9-RAG.json"
 }
}