{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "SESN2-AGING",
  "claim": "Sestrin2 inhibits Age-related pathology",
  "source": {
   "name": "Sestrin2",
   "entity": "sestrin2"
  },
  "target": {
   "name": "Age-related pathology",
   "entity": "age-related-pathology"
  },
  "effect": "inhibits",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "fly"
  ],
  "mechanism": "Losing Drosophila Sestrin produces fat accumulation, mitochondrial dysfunction, muscle degeneration and cardiac malfunction, all prevented by inhibiting TOR or activating AMPK. Sestrin therefore limits age-associated pathology in the fly.",
  "mechanism_beginner": "The only case in this atlas linking a nutrient sensor to ageing of a whole animal: fruit flies without this sensor build up fat and develop muscle and heart problems, and blocking this pathway or switching on AMPK prevents it. So the sensor holds age-related damage back. Watch what was measured – how sick the flies got, not how long they lived.",
  "context": null,
  "boundary": "Fly only, and the readout is age-related pathology: survival was never measured. No mammalian sensor-to-ageing evidence exists in this corpus.",
  "note": "Added 2026-07-29. Gap H1 previously asserted the sensors link to ZERO ageing outcomes, which was true of the corpus but not of the literature.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "LEE2010"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/SESN2-AGING/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/SESN2-AGING.json"
 }
}