{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.0",
  "corpus_snapshot": "2026-10-01T14:49:35+0200",
  "source_commit": "03bba2194c4832a1bcdfb704d54dd458ab0df021",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "RHEB-MTORC1",
  "claim": "Rheb activates mTORC1",
  "source": {
   "name": "Rheb",
   "entity": "rheb"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "activates",
  "type": "allosteric-activation",
  "directness": "direct",
  "timescale": "seconds",
  "compartment": "lyso",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "GTP-loaded Rheb binds mTORC1 at the lysosome and physically re-shapes its active site into the working conformation.",
  "mechanism_beginner": "Switched-on Rheb docks onto mTORC1 and physically reshapes it into its working form – the actual \"on\" switch.",
  "context": "Rheb must be GTP-loaded and co-located with mTORC1. Rheb is also distributed across the ER and Golgi, and which pool supplies the activating Rheb is unresolved.",
  "boundary": null,
  "note": "Convergence point: the amino-acid route delivers mTORC1 here, the growth-factor route delivers Rheb. Both required.",
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Structural",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "INOK2003",
    "SAU2003",
    "YAN2017"
   ],
   "conflicting": []
  },
  "reviewed": "2026-07-29",
  "updated": "2026-07-29",
  "api_url": "https://mtor-atlas.org/api/v1/relations/RHEB-MTORC1.json"
 }
}