{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "RAPA-MTORC2",
  "claim": "Rapamycin inhibits mTORC2",
  "source": {
   "name": "Rapamycin",
   "entity": "rapamycin"
  },
  "target": {
   "name": "mTORC2",
   "entity": "mtorc2"
  },
  "effect": "inhibits",
  "type": "complex-assembly",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "Rapamycin does not touch mTORC2 in the short term - but over days it traps free mTOR and prevents new mTORC2 from being assembled.",
  "mechanism_beginner": "Rapamycin doesn't touch mTORC2 right away, but over days it stops new mTORC2 from being built.",
  "context": null,
  "boundary": "Strictly time- and cell-type-dependent: absent acutely, present after prolonged exposure, and the sensitivity varies between cell lines. LAM2012 shows the same loss of mTORC2 signalling in mouse liver in vivo, so this is not a cell-culture-only phenomenon. Treating this edge as unconditional is a common error.",
  "boundary_tags": [
   "time-dependent",
   "tissue-specific"
  ],
  "conflict": null,
  "note": "THE key context-dependent edge. Should render dashed with an explicit 'chronic only' label. 2026-10-09: Interaction type changed complex-disassembly -> complex-assembly. Prolonged rapamycin prevents assembly of NEW mTORC2 (SAR2006); it does not disassemble existing complexes, so 'disassembly' was the wrong mechanism word. Sign stays 'inhibits' (it inhibits assembly).",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Pharmacological",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "SAR2006",
    "LAM2012"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/RAPA-MTORC2/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/RAPA-MTORC2.json"
 }
}