{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "RAPA-MTORC1",
  "claim": "Rapamycin inhibits mTORC1",
  "source": {
   "name": "Rapamycin",
   "entity": "rapamycin"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "inhibits",
  "type": "allosteric-inhibition",
  "directness": "indirect",
  "timescale": "minutes",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "Rapamycin inhibits mTORC1 only as a complex with FKBP12: the pair docks on the FRB domain beside the active site and blocks some substrates but not all, so S6K1 phosphorylation collapses while much of 4E-BP1 phosphorylation persists.",
  "mechanism_beginner": "Rapamycin, carried by its helper protein FKBP12, jams part of mTORC1 – it blocks some of what mTORC1 does but not all of it.",
  "context": null,
  "boundary": "Directness is graded indirect because the mechanism requires FKBP12, as for everolimus and the bi-sterics. Acute effect only; the chronic effect on mTORC2 is the separate RAPA-MTORC2 edge.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Structural",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "CHU1992",
    "BRO1994",
    "SAB1994",
    "SAB1995",
    "CHO1996",
    "MEI2008",
    "KAN2013",
    "FIN2002",
    "BRU1997"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/RAPA-MTORC1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/RAPA-MTORC1.json"
 }
}