{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "RAGULATOR-RAG",
  "claim": "Ragulator activates Rag GTPases",
  "source": {
   "name": "Ragulator",
   "entity": "ragulator"
  },
  "target": {
   "name": "Rag GTPases",
   "entity": "rag-gtpases"
  },
  "effect": "activates",
  "type": "scaffolding",
  "directness": "direct",
  "timescale": "constitutive",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "Ragulator does two jobs on the Rags. It tethers the Rag heterodimer to the lysosomal surface, and it acts as an unusual exchange factor: first reported as a GEF for RagA/B (BAR2012), its exchange activity was later placed on RagC, where releasing GTP unlocks the inactive state (SHE2018B). Loading RagA with GTP is done by arginine-bound SLC38A9 (see SLC38A9-RAG).",
  "mechanism_beginner": "Ragulator anchors the Rag proteins to the lysosome and also helps flip them into their \"on\" shape, together with a second protein, SLC38A9. Both jobs are shown in biochemical experiments.",
  "context": null,
  "boundary": "Human cells, Drosophila and purified recombinant proteins (BAR2012, SAN2010, SHE2018B). The exchange activity was first assigned to RagA/B and later to RagC, so the exact step is still being refined. Whole-animal and human relevance are not tested here.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "BAR2012",
    "SAN2010",
    "SHE2018B"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/RAGULATOR-RAG/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/RAGULATOR-RAG.json"
 }
}